1025967-78-5 Liftegrast

Egenskaber

Udseende hvid til off-white solid
Melting point:>163 grad (dec.)
Kogepunkt: 811,9 ± 65. 0 grad
Densitet 1,479 ± 0. 06 g/cm3
Opbevaringstemp. Hygroskopisk, -20 grad fryser, under inert atmosfære
Opløselighed DMSO (lidt, opvarmet, sonikeret), methanol (let, sonikeret)
PKA3.14 ± 0. 10

 

Anvendelse:

Lifitegrast reducerer aggregeringen af ​​hvide blodlegemer i øjet ved at blokere samspillet mellem LFA -1 og ICAM -1 og derved lindre øjenbetændelse og tørre øje -symptomer. Denne mekanisme gør, at Lifitegrast har potentiale til behandling af tør øjensygdom.

 

Synonymer:

Lifitegrast

1025967-78-5

Xiidra

Sar -1118

(S) -2- (2- (benzofuran -6- carbonyl) -5, 7- dichloro -1, 2,3, 4- tetra Hydroisoquinolin -6- carboxamido) -3- (3- (methylsulfonyl) phenyl) propanoic syre

Shp -606

L-phenylalanin, N-[[2- (6- benzofuranylcarbonyl) -5, 7- dichloro -1, 2,3, { {9}} tetrahydro -6- isoquinolinyl] carbonyl] -3- (methylsulfonyl)-

Sar1118

L-phenylalanin, N-((2- (6- benzofuranylcarbonyl) -5, 7- dichloro -1, 2,3, { {9}} tetrahydro -6- isoquinolinyl) carbonyl) -3- (methylsulfonyl)-

(2S) -2- (((2- (benzofuran -6- ylcarbonyl) -5, 7- dichloro -1, 2,3, 4- tetrah åndroisoquinolin -6- yl) carbonyl) amino) -3- (3- (methylsulfonyl) phenyl) propanoic syre

(2s) -2- [[2- (1- benzofuran -6- carbonyl) -5, 7- dichloro -3, 4- Dihydro -1 h-isoquinoline -6- carbonyl] amino] -3- (3- methylsulfonylphenyl) propanoic syre

Lifitegrast

lifitegrastum

L-phenylalanin, N-[[2- (6- benzofuranylcarbonyl) -5, 7- dichloro -1, 2,3, { {9}} tetrahydro -6- isoquinolinyl] carbonyl] -3- (methylsulfonyl)-; N-[[2- (6- benzofuranylcarbonyl) -5, 7- dichloro -1, 2,3, 4- t etrahydro -6- isoquinolinyl] carbonyl] -3- (methylsulfonyl) -l-phenylalanin; (S)

N-(2- (1- benzofuran -6- carbonyl) -5, 7- dichloro -1, 2,3, 4- te Trahydroisoquinoline -6- carbonyl) -3- (methansulfonyl) -l-phenylalanin

(S) -2- (2- (benzofuran -6- carbonyl) -5, 7- dichloro -1, 2,3, 4- tetra Hydroisoquinolin -6- carboxamido) -3- (3- (methylsulfonyl) phenyl) propanoic syre; (s) -2- (2- (benzofuran -6- carbonyl) -5, 7- dichloro {{17}, 2,3, 4- tetrahydroisoquinoline -6- carboxamido) -3- (3- (methylsulfonyl) phenyl) propanoic syre

(2S) -2- (((2- (benzofuran -6- ylcarbonyl) -5, 7- dichloro {{{{{{{{{{{{{{ yl) carbonyl) amino) -3- (3- (methylsulfonyl) phenyl) propansyre

 

 

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