920509-32-6 resmetirom

Egenskaber

Udseende gul til orange krystallinsk fast stof
Densitet 1,65 ± 0. 1 g/cm3
Opbevaringstemp. Inert atmosfære, opbevares i fryser, under -20 grad
Opløselighed DMSO: 59. 0 (max conc. Mg/ml); 135,56 (max conc. mm)
PKA3.96 ± 0. 40
 

Anvendelse:

Resmetirom er en selektiv agonist, der er målrettet mod skjoldbruskkirtelhormonreceptor beta (Thr -). Dette lægemiddel kan specifikt optages af leverceller og regulerer flere metaboliske veje i leveren ved at aktivere Thr -, hvilket opnås flere effekter, såsom at reducere akkumulering af leverfedt, fremme fedtsyremetabolisme, reducere leverinflammation og regulere kolesterolmetabolisme.

 

Synonymer:

Resmetirom

Mgl -3196

920509-32-6

Rezdiffra

2- * } yl) oxy] phenyl] -3, 5- dioxo -1, 2, 4- triazin -6- carbonitril

Forbindelse 53 [PMID: 24712661]

1,2, 4- triazin -6- carbonitril, 2- (3, 5- dichloro -4- ((1, 6- dihydro -5- (1- methylethyl) -6- ox o -3- pyridazinyl) oxy) phenyl) -2, 3,4, 5- tetrahydro -3, 5- dioxo-

2- (3, 5- dichloro -4- ((5- isopropyl -6- oxo -1, 6- dihydropyridazin -3- yd) ox y) phenyl) -3, 5- dioxo {{11}, 3,4, 5- tetrahydro- (1,2,4) triazin -6- carbonitril

Forbindelse 53 (PMID: 24712661)

1,2, 4- triazin -6- carbonitril, 2- [3, 5- dichloro -4- [[1, {9}} dihydro -5- (1- methylethyl) -6- ox o -3- pyridazinyl] oxy] phenyl] -2, 3,4, 5- tetrahydro -3, 5- dioxo-

Resmetiromum

Rezdiffra

2- (3, 5- dichloro -4- ((6- oxo -5- (propan -2- yl) -1, {6- dihydropyridazin {{{{{-3-} ) phenyl) -3, 5- dioxo -2, 3,4, {15}} tetrahydro {{16}, 2, 4- triazine -6- carbonitrile

{{0 eder } yl) oxy) phenyl) -3, 5- dioxo -1, 2, 4- triazin -6- carbonitril

2- (3, 5- dichloro -4- {[6- oxo -5- (propan -2- yl) -1, {6- dihydropyridazin {{-3-} } phenyl) -3, 5- dioxo {{12}, 3,4, 5- tetrahydro -1, 2, 4- triazine -6- carbonitrile

2- {3, 5- dichloro -4- [(5- isopropyl -6- oxo -1 H-pyridazin -3- yl) o Xy] phenyl} -3, 5- dioxo -4 h -1, 2, 4- triazin -6- carbonitril

2- (3, 5- dichloro -4- (5- isopropyl -6- oxo -1, 6- Dihydropyridazin -3- yloxy) pH enyl) -3, 5- dioxo -2, 3,4, {14}} tetrahydro -1, 2, 4- triazine -6- carbonitrile

2- (4- (1, 6- dihydro -5- isopropyl -6- oxopyridazin -3- yloxy) -3, {5- dichloroph enyl) -2, 3,4, 5- tetrahydro -3, 5- dioxo -1, 2, 4- triazine -6- carbonitrile

2- [3, 5- dichloro -4- (5- isopropyl -6- oxo -1, 6- Dihydro-pyridazin -3- yloxy ) -Phenyl] -3, 5- dioxo -2, 3,4, 5- tetrahydro- [1,2,4] triazin -6- carbonitril

2- [3, 5- dichloro -4- [[1, {5}} dihydro -5- (1- methylethyl) -6- oxo -3-} pyridazinyl ] phenyl] -2, 3,4, 5- tetrahydro -3, 5- dioxo -1, 2, 4- triazine -6- carbonitrile

 

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